SPRED2 抗体 (AA 40-298)
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Quick Overview for SPRED2 抗体 (AA 40-298) (ABIN7874694)
抗原
See all SPRED2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-298
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原理
- SPRED2 Antibody / Sprouty-related EVH1 domain-containing protein 2
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids R40-R298 from the human protein were used as the immunogen for the SPRED2 antibody.
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亚型
- IgG
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anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 120-219) antibody
SPRED2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G8 unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 120-219) antibodySPRED2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 40-298) antibodySPRED2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 120-219) antibodySPRED2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (C-Term) antibodySPRED2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 120-300) antibodySPRED2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 317-366) antibodySPRED2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 斑马鱼, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (C-Term) antibodySPRED2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 斑马鱼, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) (AA 1-418) antibodySPRED2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SPRED2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SPRED2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))
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别名
- SPRED2
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背景
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SPRED2 (Sprouty-related EVH1 domain-containing protein 2) is a member of the SPRED protein family, which negatively regulates receptor tyrosine kinase (RTK) signaling pathways. By interacting with components of the Ras/MAPK cascade, SPRED2 suppresses excessive ERK activation, thereby controlling cellular processes such as proliferation, differentiation, and migration. Researchers frequently use a SPRED2 antibody to investigate signaling dynamics and the molecular mechanisms of growth factor regulation.
SPRED2 contains an N-terminal Ena/VASP homology 1 (EVH1) domain, a central c-Kit binding domain, and a C-terminal Sprouty-related cysteine-rich domain. These structural motifs allow SPRED2 to localize to the plasma membrane and recruit signaling proteins, where it inhibits Ras and Raf activation. Employing a SPRED2 antibody allows scientists to study how this protein maintains signaling balance across a variety of cell types.
Altered expression of SPRED2 has been linked to human disease. Loss or reduction of SPRED2 function has been associated with enhanced MAPK pathway activity, which may contribute to oncogenesis and abnormal tissue growth. Additionally, SPRED2 is studied in the context of immune regulation and inflammation, where dysregulated signaling can lead to pathological outcomes. Using a SPRED2 antibody supports research into these processes and offers insight into therapeutic strategies aimed at modulating Ras/MAPK signaling.
NSJ Bioreagents offers a high-quality SPRED2 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a SPRED2 antibody from NSJ Bioreagents ensures reliable detection and reproducible performance in studies of signal transduction, cell regulation, and disease biology. -
UniProt
- Q7Z698
抗原
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