JMJD5 抗体 (AA 4-406)
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Quick Overview for JMJD5 抗体 (AA 4-406) (ABIN7874677)
抗原
See all JMJD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-406
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原理
- KDM8 Antibody / Lysine-specific demethylase 8
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human KDM8 recombinant protein (Position: D4-D406) was used as the immunogen for the KDM8 antibody.
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亚型
- IgG
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anti-Jumonji Domain Containing 5 (JMJD5) (AA 1-416) antibody
JMJD5 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (AA 36-63), (N-Term) antibodyJMJD5 适用: 人 WB 宿主: 兔 Polyclonal RB24972 unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (Middle Region) antibodyJMJD5 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (AA 151-380) antibodyJMJD5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (AA 147-416) antibodyJMJD5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (AA 72-121) antibodyJMJD5 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 猴, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (C-Term) antibodyJMJD5 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (N-Term) antibodyJMJD5 适用: 人, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (N-Term) antibodyJMJD5 适用: 人, 小鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji Domain Containing 5 (JMJD5) (AA 36-63), (N-Term) antibodyJMJD5 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the KDM8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the KDM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- JMJD5 (Jumonji Domain Containing 5 (JMJD5))
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别名
- KDM8
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背景
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KDM8 antibody detects Lysine-specific demethylase 8, a histone demethylase that regulates chromatin organization, transcription, and cell cycle progression. Encoded by the KDM8 gene on chromosome 16p12.1, this enzyme demethylates dimethylated lysine 36 on histone H3 (H3K36me2), a modification associated with transcriptional elongation and gene regulation. KDM8 plays an essential role in epigenetic control of gene expression, particularly during mitotic progression and differentiation.
KDM8, also known as JMJD5, is a member of the Jumonji C (JmjC) domain-containing family of Fe(II)- and 2-oxoglutarate-dependent oxygenases. It localizes to the nucleus and functions both as a histone demethylase and as a cofactor for cell cycle regulatory proteins such as CDK1. Through these activities, KDM8 coordinates chromatin dynamics and ensures proper metaphase alignment during mitosis.
The KDM8 antibody is widely used in epigenetics, developmental biology, and cancer research to study histone methylation control, transcriptional regulation, and chromatin remodeling. Western blot analysis detects a 47 kilodalton band corresponding to KDM8, while immunofluorescence reveals nuclear staining consistent with its chromatin-associated functions. This antibody enables examination of histone modification patterns and their effects on gene expression and cell division.
Aberrant expression of KDM8 has been linked to oncogenesis, particularly in breast and prostate cancers, where it promotes proliferation and cell cycle progression by modulating chromatin accessibility. KDM8 also interacts with p53 and ribosomal proteins to coordinate metabolic and stress responses. The KDM8 antibody provides a powerful tool for studying epigenetic regulation and transcriptional dynamics. NSJ Bioreagents offers this antibody validated for its applications, ensuring accurate detection in chromatin and gene regulation research. -
UniProt
- Q8N371
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途径
- Chromatin Binding
抗原
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