PDX1 抗体 (pan)
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Quick Overview for PDX1 抗体 (pan) (ABIN7874661)
抗原
See all PDX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-200, pan
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原理
- PDX1 Antibody / Pancreas/duodenum homeobox protein 1
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids E4-K200) was used as the immunogen for the PDX1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PDX1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PDX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
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别名
- PDX1
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背景
- PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
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UniProt
- P52945
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
抗原
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