PLD6 抗体 (AA 39-238)
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Quick Overview for PLD6 抗体 (AA 39-238) (ABIN7874591)
抗原
See all PLD6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-238
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原理
- PLD6 Antibody / Phospholipase D6 / MitoPLD
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids R39-L238) was used as the immunogen for the PLD6 antibody.
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亚型
- IgG
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anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibody
PLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB28958 unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 1-252) antibodyPLD6 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibodyPLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PLD6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PLD6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PLD6 (Phospholipase D Family, Member 6 (PLD6))
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别名
- PLD6
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背景
- PLD6 (phospholipase D family, member 6), also called MitoPLD (Mitochondrial phospholipase), is a protein-coding gene. Among its related super-pathways are choline biosynthesis III and Glycerophospholipid biosynthesis. GO annotations related to this gene include cardiolipin hydrolase activity and protein homodimerization activity. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.
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UniProt
- Q8N2A8
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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