MYBBP1A 抗体 (AA 39-1316)
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北京 101111
Quick Overview for MYBBP1A 抗体 (AA 39-1316) (ABIN7874570)
抗原
See all MYBBP1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-1316
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原理
- MYBBP1A Antibody / Myb-binding protein 1A
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived mouse MYBBP1A recombinant protein (Position: D39-R1316) was used as the immunogen for the MYBBP1A antibody.
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亚型
- IgG
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anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1104-1328) antibody
MYBBP1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1-1328) antibodyMYBBP1A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (C-Term) antibodyMYBBP1A 适用: 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1-1328) antibodyMYBBP1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1201-1250) antibodyMYBBP1A 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyMYBBP1A 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 258-287), (N-Term) antibodyMYBBP1A 适用: 人 WB 宿主: 兔 Polyclonal RB23244 unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 450-500) antibodyMYBBP1A 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyMYBBP1A 适用: 人 IHC, ELISA, IF 宿主: 兔 Monoclonal 3A1 unconjugated Recombinant Antibody
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyKD Validated MYBBP1A 适用: 人 WB 宿主: 小鼠 Monoclonal 25GB3890 unconjugated
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应用备注
- Optimal dilution of the MYBBP1A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))
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别名
- MYBBP1A
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背景
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MYBBP1A antibody detects Myb-binding protein 1A, a nucleolar transcriptional regulator that modulates gene expression, chromatin structure, and cell cycle progression. Encoded by the MYBBP1A gene on chromosome 17p13.3, this large nuclear protein was originally identified through its interaction with the Myb oncoprotein, but it also binds multiple transcription factors including p53, NF?B, and STAT3. MYBBP1A contains several acidic and coiled-coil domains that facilitate protein-protein interactions and nucleolar localization sequences that target it to the nucleolus under normal growth conditions. It functions as both a transcriptional coactivator and corepressor, integrating stress responses with cell cycle control.
MYBBP1A plays a key role in ribosome biogenesis and nucleolar stress signaling. Upon cellular stress or energy depletion, MYBBP1A translocates from the nucleolus to the nucleoplasm, where it enhances p53 acetylation and activation, promoting cell cycle arrest and apoptosis. It also suppresses c-Myb-driven transcription to prevent uncontrolled proliferation. Through these mechanisms, MYBBP1A acts as a tumor suppressor and regulator of growth arrest. Depletion of MYBBP1A leads to impaired rRNA processing and increased genomic instability. Dysregulation of its expression has been reported in renal carcinoma, hepatocellular carcinoma, and hematologic malignancies.
The MYBBP1A antibody is used in cancer biology and transcriptional regulation studies to detect Myb-binding protein 1A localization and abundance. Western blot analysis typically identifies a ~150 kilodalton band, while immunofluorescence shows predominant nucleolar staining with redistribution upon stress. Because MYBBP1A interacts with both histone-modifying enzymes and transcriptional machinery, it is a critical factor for understanding nucleolar function and epigenetic regulation. The antibody is effective in chromatin immunoprecipitation, immunohistochemistry, and nuclear fractionation assays. The MYBBP1A antibody therefore supports research on tumor suppression, transcriptional control, and nucleolar biology. NSJ Bioreagents provides this reagent validated for high specificity and reproducibility across applications. -
UniProt
- Q7TPV4
抗原
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