TMEM201 抗体 (AA 38-591)
The 兔 多克隆 anti-TMEM201 antibody (ABIN7874512) specifically detects TMEM201 in WB, ELISA 和 FACS.
The antibody is reactive with 人 samples.
产品编号 ABIN7874512
发货至:
中国
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Quick Overview for TMEM201 抗体 (AA 38-591) (ABIN7874512)
抗原
See all TMEM201 抗体
TMEM201
(Transmembrane Protein 201 (TMEM201))
适用
人
宿主
兔
克隆类型
多克隆
标记
This TMEM201 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
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抗原表位
- AA 38-591
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原理
- TMEM201 Antibody / Transmembrane protein 201
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TMEM201 recombinant protein (Position: R38-R591) was used as the immunogen for the TMEM201 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TMEM201 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TMEM201 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TMEM201 (Transmembrane Protein 201 (TMEM201))
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别名
- TMEM201
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背景
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TMEM201 Antibody is used to study Transmembrane protein 201, an inner nuclear membrane protein that helps organize the nuclear envelope and coordinate nucleus-to-cytoskeleton communication. Localized at the inner nuclear membrane, Transmembrane protein 201 interacts with elements of the LINC complex that connect nuclear lamins to actin cables, supporting nuclear positioning, cell polarization, and directed migration. By anchoring the nucleus to retrograde actin flow through transmembrane actin-associated nuclear lines, Transmembrane protein 201 influences how cells orient and move in response to external cues, a process relevant to development, wound repair, and vascular remodeling.
Biochemically, Transmembrane protein 201 contains luminal and cytoplasmic regions that permit associations with lamins and cytoskeletal adaptors. These interactions help maintain nuclear envelope integrity and may tune mechanotransduction, allowing cells to translate mechanical forces into gene-regulatory outcomes. Perturbation of Transmembrane protein 201 can disrupt centrosome orientation and impair cell polarity, emphasizing its role at the interface of structure and signaling. In endothelial systems, increased Transmembrane protein 201 activity has been linked with enhanced migration during angiogenic sprouting, underscoring its relevance to vascular biology.
Researchers use TMEM201 Antibody to define inner nuclear membrane architecture by immunofluorescence, co-localize the protein with lamins or SUN/KASH components, and quantify expression under conditions that alter cytoskeletal tension. In immunoblotting, the antibody detects endogenous Transmembrane protein 201 and can monitor isoform abundance or post-translational changes across cell states. Immunoprecipitation with TMEM201 Antibody enables mapping of protein partners at the nuclear envelope, supporting studies that connect nuclear mechanics to transcriptional control and cell fate decisions. Because nuclear positioning and mechanosensitive signaling influence differentiation, immunity, and cancer invasion, this reagent supports a wide set of experimental questions.
The TMEM201 Antibody from NSJ Bioreagents provides dependable performance across imaging and biochemical workflows, allowing laboratories to standardize detection in side-by-side studies of nuclear envelope organization, polarized migration, and endothelial biology. In development models, it can reveal how nuclear anchorage guides morphogenesis, in pathobiology, it helps test whether altered nuclear-cytoskeletal coupling contributes to invasive behavior or impaired tissue repair. For teams integrating live-cell imaging, traction force microscopy, or RNA-seq, pairing functional assays with precise localization data from this antibody can clarify how structural changes at the inner nuclear membrane shape downstream transcriptional programs.
As interest grows in how nuclear architecture governs cell behavior, TMEM201 Antibody provides a practical bridge between nuclear envelope structure and systems-level outcomes. Its use in standard immunocytochemistry, tissue immunohistochemistry, and pulldown experiments makes it a versatile tool for dissecting nuclear positioning, mechanotransduction, and angiogenesis, while helping connect biophysical cues to gene regulation and phenotype in both normal physiology and disease contexts.
TMEM201 Antibody supports rigorous inquiries into nuclear mechanics with a single, reliable probe that integrates cleanly into multicolor imaging, gel-based quantification, and interactome discovery workflows. -
UniProt
- Q5SNT2
抗原
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