FOXA1 抗体 (AA 372-472)
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Quick Overview for FOXA1 抗体 (AA 372-472) (ABIN7874432)
抗原
See all FOXA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 372-472
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原理
- FOXA1 Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein (amino acids 372-472) was used as the immunogen for the FOXA1 antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the FOXA1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the FOXA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- FOXA1 (Forkhead Box A1 (FOXA1))
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别名
- FOXA1
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背景
- The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1, and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
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UniProt
- P55317
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
抗原
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