EIF3H 抗体 (AA 37-352)
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Quick Overview for EIF3H 抗体 (AA 37-352) (ABIN7874398)
抗原
See all EIF3H 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 37-352
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原理
- EIF3H Antibody / Eukaryotic translation initiation factor 3 subunit H
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human EIF3H recombinant protein (Position: K37-N352) was used as the immunogen for the EIF3H antibody.
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亚型
- IgG
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anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 80-340) antibody
EIF3H 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 234-263), (C-Term) antibodyEIF3H 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20154 unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) antibodyEIF3H 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 152-250) antibodyEIF3H 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (N-Term) antibodyEIF3H 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 80-340) antibodyEIF3H 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) antibodyEIF3H 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 152-250) antibodyEIF3H 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 1-352) antibodyEIF3H 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C6 unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) (AA 246-295) antibodyEIF3H 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, 非洲爪蟾, Pig, 小鸡, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the EIF3H antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the EIF3H antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H))
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别名
- EIF3H
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背景
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EIF3H Antibody is used to study Eukaryotic translation initiation factor 3 subunit H, a core component of the eIF3 complex that orchestrates early steps of protein synthesis. As part of the multi-subunit eIF3 scaffold, Eukaryotic translation initiation factor 3 subunit H helps recruit the 40S ribosomal subunit, stabilizes the ternary complex, and promotes mRNA attachment and scanning to locate the start codon. By coordinating factor exchange and ribosome positioning, Eukaryotic translation initiation factor 3 subunit H contributes to the efficiency and selectivity of translation initiation, a checkpoint that powerfully shapes proteome output and cellular phenotype.
Functionally, Eukaryotic translation initiation factor 3 subunit H supports assembly of the 43S pre-initiation complex and helps maintain interactions with eIF4F-bound mRNAs. Perturbations in subunit stoichiometry can shift translation of specific mRNA cohorts, including transcripts with structured 5' UTRs or upstream open reading frames. In cancer models, amplification or overexpression of Eukaryotic translation initiation factor 3 subunit H correlates with elevated global translation and selective enhancement of growth-promoting messages. These properties make EIF3H Antibody valuable for charting how initiation control intersects with oncogenic signaling and stress adaptation.
In the laboratory, EIF3H Antibody enables detection of the native subunit in immunoblotting, monitors changes during serum starvation or mTOR pathway modulation, and supports co-immunoprecipitation to define interactions within the eIF3 complex. In immunofluorescence, the antibody reveals cytoplasmic distribution patterns that can be aligned with ribosomal markers or stress granule components. Researchers coupling EIF3H Antibody with polysome profiling, ribosome footprinting, or cap-binding assays can connect subunit abundance to translational throughput and transcript selectivity. Because initiation control influences cell growth, differentiation, and stress resilience, accurate measurement of this subunit helps interpret the translational state of diverse cell types.
The EIF3H Antibody from NSJ Bioreagents is optimized for robust detection across common cell lines and tissues, integrating cleanly into workflows that probe translation factor dynamics, response to kinase inhibitors, or adaptive reprogramming under hypoxia and nutrient limitation. In biomarker studies, it can help assess whether elevated Eukaryotic translation initiation factor 3 subunit H accompanies genomic gains at the EIF3H locus and whether this associates with proliferative phenotypes. In mechanistic projects, the antibody supports mapping of subunit-subunit interactions and evaluation of how initiation factor balance governs selective translation under stress or therapy.
As translation control emerges as a central driver of cell behavior, EIF3H Antibody provides a dependable means to quantify and localize a key eIF3 subunit, enabling researchers to connect molecular initiation events to system-level outcomes in development, cancer, and stress biology. -
UniProt
- O15372
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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