SHE 抗体 (AA 36-495)
The 兔 多克隆 anti-SHE antibody is suitable to detect SHE in samples from 人, 小鼠 和 大鼠. It has been validated for ELISA, WB, IHC, IF, FACS 和 ICC.
产品编号 ABIN7874322
发货至:
中国
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Quick Overview for SHE 抗体 (AA 36-495) (ABIN7874322)
抗原
SHE
(Src Homology 2 Domain Containing E (SHE))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This SHE antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
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抗原表位
- AA 36-495
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原理
- SHE Antibody / SH2 domain-containing adapter protein E
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SHE recombinant protein (Position: L36-H495) was used as the immunogen for the SHE antibody.
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亚型
- IgG
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anti-Src Homology 2 Domain Containing E (SHE) (AA 2-162) antibody
SHE 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SHE antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SHE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SHE (Src Homology 2 Domain Containing E (SHE))
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别名
- SHE
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背景
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SHE antibody detects SH2 domain-containing adapter protein E, a cytoplasmic signaling adaptor that mediates growth factor and cytokine receptor signaling. Encoded by the SHE gene on chromosome 2p13.3, this protein functions downstream of receptor tyrosine kinases and cytokine receptors, facilitating the recruitment of effector molecules involved in cell growth, differentiation, and survival. By coupling phosphorylated receptors to intracellular signaling cascades, SHE helps coordinate pathways such as MAPK/ERK and PI3K/AKT.
SHE contains a central SH2 domain that binds phosphotyrosine motifs on activated receptors and associated kinases. Through its modular architecture, it acts as a scaffold that brings kinases and transcriptional regulators into close proximity, ensuring precise and timely propagation of receptor-initiated signals. SHE interacts with proteins such as EGFR, JAK2, and STAT3, influencing processes from hematopoietic differentiation to epithelial cell proliferation.
The SHE antibody is widely used in cell signaling, oncology, and hematology research to study adaptor-mediated signal transduction and receptor dynamics. Western blot analysis identifies a 62 kilodalton band corresponding to SHE, while immunofluorescence shows cytoplasmic and perinuclear localization in stimulated cells. This antibody is essential for dissecting receptor coupling events and understanding how adaptor proteins coordinate cellular responses to growth factors.
In cancer and immune regulation, altered SHE expression or phosphorylation disrupts normal signal transduction, leading to abnormal cell proliferation and survival. Overactivation of SHE-associated signaling contributes to tumor progression, while its suppression can impair cytokine responsiveness and differentiation. The SHE antibody provides a sensitive tool for evaluating these effects and monitoring adaptor function in normal and disease contexts. NSJ Bioreagents validates this antibody for its applications, ensuring dependable and reproducible performance for studies on receptor and kinase signaling networks. -
UniProt
- Q5VZ18
抗原
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