PNLIP 抗体 (pan)
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北京 101111
Quick Overview for PNLIP 抗体 (pan) (ABIN7874313)
抗原
See all PNLIP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 36-404, pan
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原理
- PNLIP Antibody / Pancreatic Lipase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Pancreatic Lipase/PNLIP recombinant protein (Position: I36-D404) was used as the immunogen for the PNLIP antibody.
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亚型
- IgG
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anti-Pancreatic Lipase (PNLIP) antibody
PNLIP 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) antibodyPNLIP 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 166-465) antibodyPNLIP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 1-465) antibodyPNLIP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 1-465) antibodyPNLIP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (C-Term) antibodyPNLIP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 325-374) antibodyPNLIP 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 166-465) antibodyPNLIP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 201-412) antibodyPNLIP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic Lipase (PNLIP) (AA 47-280) antibodyPNLIP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PNLIP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PNLIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PNLIP (Pancreatic Lipase (PNLIP))
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别名
- PNLIP
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背景
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PNLIP antibody detects Pancreatic lipase, encoded by the PNLIP gene. Pancreatic lipase is a secreted digestive enzyme essential for hydrolyzing dietary triglycerides into free fatty acids and monoglycerides in the small intestine. PNLIP antibody provides researchers with a critical reagent for studying lipid digestion, gastrointestinal biology, and disorders of fat absorption.
Pancreatic lipase is secreted by the exocrine pancreas into the duodenum, where it functions in concert with bile salts and colipase to emulsify and degrade triglycerides. Research using PNLIP antibody has shown that the enzyme specifically catalyzes the hydrolysis of ester bonds at the sn-1 and sn-3 positions of triglycerides, leaving monoglycerides for absorption. Its central role in fat metabolism underscores its importance for nutritional physiology.
Studies with PNLIP antibody have revealed that deficiency in pancreatic lipase causes steatorrhea and fat malabsorption syndromes, leading to poor nutrient uptake, weight loss, and deficiency of fat-soluble vitamins. Mutations in the PNLIP gene have been linked to congenital pancreatic lipase deficiency, a rare autosomal recessive disorder. In addition, reduced activity is observed in chronic pancreatitis and cystic fibrosis, making pancreatic lipase an important biomarker of pancreatic function.
Beyond digestion, research using PNLIP antibody has highlighted its potential role in metabolic disease. Altered pancreatic lipase activity has been associated with obesity, insulin resistance, and dyslipidemia. Pharmacological inhibitors of pancreatic lipase, such as orlistat, are clinically used to reduce fat absorption in obesity management, emphasizing the therapeutic relevance of this enzyme.
PNLIP antibody is widely used in immunohistochemistry, western blotting, and ELISA. Immunohistochemistry highlights expression in pancreatic acinar cells, western blotting quantifies enzyme levels in pancreatic extracts, and ELISA measures circulating lipase in serum. These applications make PNLIP antibody indispensable for digestive and metabolic research.
By supplying validated PNLIP antibody reagents, NSJ Bioreagents supports studies into lipid metabolism, pancreatic disease, and digestion. Detection of Pancreatic lipase provides researchers with insight into how lipolytic enzymes regulate nutrient absorption and metabolic health. -
UniProt
- P16233
抗原
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