SMAD7 抗体 (AA 353-388)
Our Local Distributor
北京 101111
Quick Overview for SMAD7 抗体 (AA 353-388) (ABIN7874259)
抗原
See all SMAD7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 353-388
-
原理
- SMAD7 Antibody / MADH7
-
纯化方法
- Antigen affinity purified
-
免疫原
- Recombinant human protein (amino acids R353-Q388) was used as the immunogen for the SMAD7 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the SMAD7 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the SMAD7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
-
别名
- SMAD7
-
背景
- Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
-
UniProt
- O15105
-
途径
- Interferon-gamma Pathway, Cell-Cell Junction Organization
抗原
-