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LDLR 抗体 (AA 35-843)

The 兔 多克隆 anti-LDLR antibody is suitable to detect LDLR in samples from 人 和 大鼠. It has been validated for WB, ELISA, FACS 和 IHC (p).
产品编号 ABIN7874181
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for LDLR 抗体 (AA 35-843) (ABIN7874181)

抗原

See all LDLR 抗体
LDLR (Low Density Lipoprotein Receptor (LDLR))

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This LDLR antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 35-843

    原理

    LDL Receptor Antibody / LDLR

    纯化方法

    Affinity purified

    免疫原

    Recombinant human protein (amino acids Q35-D843) was used as the immunogen for the LDL Receptor antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the LDL Receptor antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the LDL Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    LDLR (Low Density Lipoprotein Receptor (LDLR))

    别名

    LDL Receptor

    背景

    In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

    UniProt

    P01130

    途径

    Hepatitis C, Lipid Metabolism
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