TRIM23 抗体 (AA 35-406)
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Quick Overview for TRIM23 抗体 (AA 35-406) (ABIN7874166)
抗原
See all TRIM23 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 35-406
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原理
- TRIM23 Antibody / Tripartite motif-containing protein 23
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TRIM23 recombinant protein (Position: E35-R406) was used as the immunogen for the TRIM23 antibody.
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亚型
- IgG
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anti-Tripartite Motif Containing 23 (TRIM23) (AA 1-110) antibody
TRIM23 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (N-Term) antibodyTRIM23 适用: 人 WB, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (AA 1-280) antibodyTRIM23 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (AA 201-300) antibodyTRIM23 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) antibodyTRIM23 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (AA 1-110) antibodyTRIM23 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E8 unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (AA 1-280) antibodyTRIM23 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) antibodyTRIM23 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4545 unconjugated Recombinant Antibody
anti-Tripartite Motif Containing 23 (TRIM23) (AA 147-175), (N-Term) antibodyTRIM23 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33243 unconjugated
anti-Tripartite Motif Containing 23 (TRIM23) (C-Term) antibodyTRIM23 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TRIM23 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TRIM23 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TRIM23 (Tripartite Motif Containing 23 (TRIM23))
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别名
- TRIM23
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背景
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TRIM23 antibody detects Tripartite motif-containing protein 23, a multifunctional E3 ubiquitin ligase involved in autophagy, vesicle trafficking, and innate immunity. The UniProt recommended name is Tripartite motif-containing protein 23 (TRIM23). This cytoplasmic protein belongs to the TRIM family, characterized by RING, B-box, and coiled-coil domains mediating protein-protein interactions and ubiquitin ligase activity.
Functionally, TRIM23 antibody identifies a 586-amino-acid protein that regulates signaling complexes and autophagy. TRIM23 ubiquitinates and activates TBK1 kinase, promoting antiviral autophagy and interferon responses. It also coordinates endomembrane trafficking by acting as an Arf GAP (GTPase-activating protein), linking vesicular dynamics to immune signaling.
The TRIM23 gene is located on chromosome 5q12.3 and is expressed in multiple tissues, with highest levels in brain, lung, and immune cells. Through its dual ubiquitin ligase and Arf GAP activities, TRIM23 integrates membrane trafficking and host defense. It contributes to selective autophagy of pathogens and protein aggregates.
Pathologically, altered TRIM23 expression has been associated with neurodegeneration, viral infection, and cancer. In neurons, TRIM23 maintains axonal homeostasis, while in immune cells it regulates autophagic responses. Research using TRIM23 antibody supports studies in innate immunity, autophagy, and vesicle biology.
TRIM23 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect E3 ligases and autophagy regulators. NSJ Bioreagents provides TRIM23 antibody reagents optimized for studies in protein ubiquitination, intracellular trafficking, and immune signaling.
Structurally, Tripartite motif-containing protein 23 features a RING finger domain for E3 ligase activity, B-box and coiled-coil domains for dimerization, and a C-terminal ARF GAP domain. This antibody supports detailed analysis of TRIM23's regulatory roles in autophagy and innate immune signaling. -
UniProt
- P36406
抗原
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