P5CS 抗体 (AA 35-204)
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Quick Overview for P5CS 抗体 (AA 35-204) (ABIN7874156)
抗原
See all P5CS (ALDH18A1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 35-204
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原理
- Zebrafish Aldh18a1 Antibody / Glutamate 5-kinase / P5cs
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish P5CS/ALDH18A1 recombinant protein (amino acids R35-A204) was used as the immunogen for the Zebrafish Aldh18a1 antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Aldh18a1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Aldh18a1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))
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别名
- Aldh18a1
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背景
- Delta-1-pyrroline-5-carboxylate synthetase (P5CS) is an enzyme that in humans is encoded by the ALDH18A1 gene. This gene is mapped to 10q24.1. This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
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UniProt
- A4IGC8
抗原
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