Vitamin D-Binding Protein 抗体 (AA 35-175)
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Quick Overview for Vitamin D-Binding Protein 抗体 (AA 35-175) (ABIN7874135)
抗原
See all Vitamin D-Binding Protein (GC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 35-175
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原理
- VDBP Antibody / Vitamin D binding protein / GC
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 35-175 was used as the immunogen for the VDBP antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the VDBP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the VDBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Vitamin D-Binding Protein (GC)
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别名
- VDBP
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背景
- Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.
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UniProt
- P02774
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途径
- Metabolism of Steroid Hormones and Vitamin D, Monocarboxylic Acid Catabolic Process
抗原
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