MASTL 抗体 (AA 34-872)
Our Local Distributor
北京 101111
Quick Overview for MASTL 抗体 (AA 34-872) (ABIN7874094)
抗原
See all MASTL 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 34-872
-
原理
- MASTL Antibody / Microtubule-associated serine/threonine-protein kinase-like
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human MASTL recombinant protein (Position: E34-L872) was used as the immunogen for the MASTL antibody.
-
亚型
- IgG
-
-
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (C-Term) antibody
MASTL 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (AA 612-740) antibodyMASTL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) antibodyMASTL 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22931 unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) antibodyMASTL 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (AA 550-600) antibodyMASTL 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (AA 550-600) antibodyMASTL 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) antibodyMASTL 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 235CT7-8-2-3 unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) antibodyMASTL 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (C-Term) antibodyMASTL 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) (AA 1-879) antibodyMASTL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4B4-1B11 unconjugated
-
-
应用备注
- Optimal dilution of the MASTL antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the MASTL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))
-
别名
- MASTL
-
背景
-
MASTL antibody detects Microtubule-associated serine/threonine-protein kinase-like, encoded by the MASTL gene. Microtubule-associated serine/threonine-protein kinase-like, also known as Greatwall kinase, is a mitotic kinase that regulates cell cycle progression by controlling phosphatase activity. MASTL antibody provides researchers with a critical reagent for studying mitosis, cell division, and cancer biology.
Greatwall kinase functions by phosphorylating proteins such as ENSA and ARPP19, which in turn inhibit the phosphatase PP2A-B55. Research using MASTL antibody has shown that this inhibition is necessary to maintain phosphorylation of mitotic substrates during cell division. By suppressing premature dephosphorylation, MASTL ensures orderly progression through mitosis and faithful chromosome segregation.
Studies with MASTL antibody have revealed that depletion of MASTL results in defective chromosome condensation, premature mitotic exit, and genomic instability. These defects highlight the essential role of MASTL in controlling mitotic events. In mouse models, loss of MASTL leads to embryonic lethality, confirming its importance in development.
Dysregulation of Microtubule-associated serine/threonine-protein kinase-like has been associated with cancer. Research using MASTL antibody has shown that overexpression drives proliferation and correlates with poor prognosis in breast, lung, and colorectal cancers. Its role in sustaining mitotic kinase activity makes it a potential therapeutic target for anti-cancer therapies focused on disrupting mitotic progression.
Beyond cancer, MASTL influences responses to DNA damage. Research using MASTL antibody has demonstrated that the kinase helps coordinate checkpoint recovery and cell cycle re-entry after genotoxic stress. This connection links mitotic regulation to DNA repair pathways and broadens the scope of MASTL function.
MASTL antibody is widely applied in western blotting, immunohistochemistry, and kinase assays. Western blotting quantifies expression in proliferating cells, immunohistochemistry highlights localization in tumors, and kinase assays confirm activity on ENSA and ARPP19. These applications make MASTL antibody indispensable for cell cycle and oncology research.
By providing validated MASTL antibody reagents, NSJ Bioreagents supports studies into mitotic control, checkpoint signaling, and cancer. Detection of Microtubule-associated serine/threonine-protein kinase-like provides researchers with insight into how kinases regulate cell division and disease. -
UniProt
- Q96GX5
抗原
-
