SCML2 抗体 (AA 337-647)
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Quick Overview for SCML2 抗体 (AA 337-647) (ABIN7874057)
抗原
See all SCML2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 337-647
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原理
- SCML2 Antibody / Sex comb on midleg-like protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SCML2 recombinant protein (Position: D337-I647) was used as the immunogen for the SCML2 antibody.
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亚型
- IgG
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anti-Sex Comb On Midleg-Like 2 (SCML2) (AA 251-350) antibody
SCML2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Sex Comb On Midleg-Like 2 (SCML2) antibodySCML2 适用: 人 WB, DB 宿主: 小鼠 Monoclonal SCMAD14A unconjugated
anti-Sex Comb On Midleg-Like 2 (SCML2) (AA 466-620) antibodySCML2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sex Comb On Midleg-Like 2 (SCML2) (Internal Region) antibodySCML2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sex Comb On Midleg-Like 2 (SCML2) (AA 348-375) antibodySCML2 适用: 人 WB 宿主: 兔 Polyclonal RB37628 unconjugated
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应用备注
- Optimal dilution of the SCML2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SCML2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SCML2 (Sex Comb On Midleg-Like 2 (SCML2))
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别名
- SCML2
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背景
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SCML2 antibody detects Sex comb on midleg-like protein 2, a Polycomb group protein involved in chromatin silencing and transcriptional repression. The UniProt recommended name is Sex comb on midleg-like protein 2 (SCML2). This epigenetic regulator participates in the formation of Polycomb repressive complexes that maintain gene silencing during development and differentiation.
Functionally, SCML2 antibody identifies a 715-amino-acid nuclear protein containing SAM and MBT domains that mediate protein-protein and chromatin interactions. SCML2 binds histone tails modified by methylation, such as H3K9me and H4K20me, to recruit other Polycomb factors and repress transcription. It is particularly enriched in testis, suggesting specialized functions in germ cell chromatin organization.
The SCML2 gene is located on the X chromosome (Xp22.12) and is expressed in germ cells, embryonic tissues, and certain somatic cells. SCML2 coordinates chromatin compaction and transcriptional silencing by recognizing repressive histone marks and interacting with PRC1 components. It contributes to maintaining stem cell identity and regulating spermatogenesis.
Pathologically, altered SCML2 expression has been linked to developmental defects, infertility, and cancer. Dysregulation may disrupt Polycomb-mediated silencing, leading to aberrant gene expression and loss of epigenetic stability. Research using SCML2 antibody aids in studying chromatin biology, gene silencing, and germline development.
SCML2 antibody is validated for western blotting, chromatin immunoprecipitation, and immunofluorescence to detect Polycomb group proteins. NSJ Bioreagents provides SCML2 antibody reagents optimized for studies in epigenetics, germ cell biology, and transcriptional regulation.
Structurally, Sex comb on midleg-like protein 2 contains a sterile alpha motif (SAM) domain for protein dimerization and two MBT repeats that bind methylated histones. This antibody enables research into SCML2's role in epigenetic repression and chromatin organization. -
UniProt
- Q9UQR0
抗原
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