MYCN 抗体 (AA 335-463)
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Quick Overview for MYCN 抗体 (AA 335-463) (ABIN7874046)
抗原
See all MYCN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 335-463
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原理
- MYCN Antibody / n-Myc
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant human MYCN protein (within amino acids 335-463) was used as the immunogen for the MYCN antibody.
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亚型
- IgG1
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应用备注
- Optimal dilution of the MYCN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MYCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MYCN (N-Myc Proto-Oncogene Protein (MYCN))
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别名
- MYCN
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背景
- The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.
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UniProt
- P04198
抗原
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