TYR 抗体 (AA 332-474)
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Quick Overview for TYR 抗体 (AA 332-474) (ABIN7874028)
抗原
See all TYR 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 332-474
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原理
- Tyrosinase Antibody / TYR (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 332-474 was used as the immunogen for the Tyrosinase antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Tyrosinase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the Tyrosinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TYR (Tyrosinase (TYR))
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别名
- Tyrosinase
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背景
- Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
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UniProt
- P14679
抗原
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