SEZ6L2 抗体 (AA 33-910)
The 兔 多克隆 anti-SEZ6L2 antibody (ABIN7874017) specifically detects SEZ6L2 in WB, FACS, ELISA 和 IHC.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7874017
发货至:
中国
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Quick Overview for SEZ6L2 抗体 (AA 33-910) (ABIN7874017)
抗原
See all SEZ6L2 抗体
SEZ6L2
(Seizure Related 6 Homolog Like 2 (SEZ6L2))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This SEZ6L2 antibody is un-conjugated
应用范围
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
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抗原表位
- AA 33-910
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原理
- SEZ6L2 Antibody / Seizure 6-like protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SEZ6L2 recombinant protein (Position: E33-I910) was used as the immunogen for the SEZ6L2 antibody.
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亚型
- IgG
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anti-Seizure Related 6 Homolog Like 2 (SEZ6L2) (AA 879-907), (C-Term) antibody
SEZ6L2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB25788 unconjugated
anti-Seizure Related 6 Homolog Like 2 (SEZ6L2) (AA 879-907) antibodySEZ6L2 适用: 人 WB, FACS, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SEZ6L2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SEZ6L2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SEZ6L2 (Seizure Related 6 Homolog Like 2 (SEZ6L2))
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别名
- SEZ6L2
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背景
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SEZ6L2 antibody detects Seizure 6-like protein 2, a type I transmembrane glycoprotein implicated in synaptic development, neural signaling, and brain homeostasis. SEZ6L2 belongs to the seizure-related gene family and is involved in regulating excitatory synapse formation and neuronal communication. The SEZ6L2 antibody is widely used in neuroscience, neurodevelopmental, and psychiatric disorder research to study synapse regulation and neuronal signaling pathways.
SEZ6L2 is encoded by the SEZ6L2 gene located on human chromosome 16p11.2. The protein is approximately 922 amino acids long and contains three CUB domains and several complement control protein (CCP) repeats, which facilitate protein interactions in the extracellular environment. SEZ6L2 localizes to the neuronal plasma membrane and is enriched in dendritic and axonal compartments.
The SEZ6L2 antibody detects a 100 kilodalton band by western blot and reveals punctate synaptic staining in neuronal cultures. SEZ6L2 participates in the regulation of synaptic vesicle cycling, neuronal excitability, and calcium-dependent signaling. It also modulates the maturation of AMPA receptors, influencing excitatory synaptic transmission and plasticity. In the central nervous system, SEZ6L2 contributes to circuit development and synaptic pruning.
Mutations or deletions of SEZ6L2 have been linked to autism spectrum disorder, intellectual disability, and schizophrenia, reflecting its critical role in neural connectivity. Dysregulation of SEZ6L2 expression affects neuronal survival and synaptic balance, contributing to altered neurotransmission and cognitive dysfunction. It is also expressed in certain cancers, where it may promote cell adhesion and metastasis.
As a neuronal surface protein involved in communication and network formation, SEZ6L2 serves as a valuable target for studying synaptic biology and neurological disease mechanisms. NSJ Bioreagents provides a validated SEZ6L2 antibody optimized for its applications, supporting research into neuronal connectivity, synaptic regulation, and neurodevelopmental disorders. -
UniProt
- Q6UXD5
抗原
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