SLC38A9 抗体 (AA 33-450)
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Quick Overview for SLC38A9 抗体 (AA 33-450) (ABIN7874002)
抗原
See all SLC38A9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-450
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原理
- SLC38A9 Antibody / URLC11
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived human recombinant protein (amino acids D33-Q450) was used as the immunogen for the SLC38A9 antibody.
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亚型
- IgG
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anti-Solute Carrier Family 38, Member 9 (SLC38A9) (AA 1-119) antibody
SLC38A9 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 38, Member 9 (SLC38A9) (AA 101-115), (Intracellular) antibodySLC38A9 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 38, Member 9 (SLC38A9) (AA 218-267) antibodySLC38A9 适用: 人, 犬, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SLC38A9 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SLC38A9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))
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别名
- SLC38A9
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背景
- Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. Sodium-coupled neutral amino acid transporter 9 (SLC38A9) is a lysosomal amino acid transporter, involved in the regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity in response to amino acid levels within the lysosomal lumen. A sodium-couple amino acid transporter at the lysosome, SLC38A9, senses arginine from within the lysosome to convey arginine sufficiency to mTORC1. SLC38A9 forms a complex with other lysosomal resident proteins including the v-ATPase and a pentameric complex called Ragulator. v-ATPase function is necessary for mTORC1 activation, but the molecular mechanism of this regulation is currently unclear2. Ragulator binds strongly to the Rag GTPases and was shown to function as a guanine exchange factor (GEF) for RagA/B. Potentially SLC38A9 and the v-ATPase are able to regulate mTORC1 activity by modulating Ragulatori 1/2s GEF activity. RagA/B is not the only Rag GTPase that is regulated, but a Folliculin-FNIP2 complex is a GAP for RagC/D. In short, SLC38A9 is a functional component of the lysosomal amino acid sensing machinery involved in the control of mTORC1 activity, that underlies the regulation of the metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels.
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UniProt
- Q8NBW4
抗原
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