ANTXR1 抗体 (AA 33-301)
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Quick Overview for ANTXR1 抗体 (AA 33-301) (ABIN7873996)
抗原
See all ANTXR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-301
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原理
- TEM8 Antibody / Anthrax toxin receptor / ATR / ANTXR1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids E33-D301) was used as the immunogen for the TEM8 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TEM8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TEM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))
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别名
- TEM8
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背景
- Anthrax toxin receptor 1 (ANTXR1 or also known as TEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
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UniProt
- Q9H6X2
抗原
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