SUN1 抗体 (AA 32-619)
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Quick Overview for SUN1 抗体 (AA 32-619) (ABIN7873935)
抗原
See all SUN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 32-619
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原理
- SUN1 Antibody / Sad1/UNC-84 domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SUN1 recombinant protein (Position: D32-E619) was used as the immunogen for the SUN1 antibody.
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亚型
- IgG
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anti-Sad1 and UNC84 Domain Containing 1 (SUN1) (N-Term) antibody
SUN1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) (AA 1-257) antibodySUN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) antibodyKD Validated SUN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2575 unconjugated Recombinant Antibody
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) antibodySUN1 适用: 人 WB, IF, ICC, IP 宿主: 兔 Chimeric unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) (AA 1-257) antibodySUN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D10 unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) antibodySUN1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) (AA 2-105) antibodySUN1 适用: Arabidopsis thaliana WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sad1 and UNC84 Domain Containing 1 (SUN1) (AA 22-173) antibodySUN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SUN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SUN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))
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别名
- SUN1
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背景
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SUN1 antibody detects Sad1/UNC-84 domain-containing protein 1, encoded by the SUN1 gene on chromosome 7p22.3. SUN1 antibody is widely used in nuclear envelope, cytoskeletal, and cell structure research. SUN1 is an inner nuclear membrane protein that interacts with KASH domain proteins at the outer nuclear membrane to form the LINC (linker of nucleoskeleton and cytoskeleton) complex. This complex physically connects the nuclear interior with the cytoskeleton, enabling nuclear positioning, mechanotransduction, and chromosome dynamics.
Structurally, SUN1 is a ~90 kDa type II transmembrane protein with a conserved SUN domain that extends into the perinuclear space. It anchors to the nuclear lamina and interacts with chromatin-associated proteins inside the nucleus. SUN1 can heterodimerize with SUN2 to form diverse LINC complexes. Expression is ubiquitous, with enrichment in proliferating and differentiating cells.
Functionally, SUN1 regulates nuclear migration, anchorage, and mechanotransduction. It is essential for meiotic chromosome pairing, telomere tethering, and centrosome-nucleus coupling. SUN1 also contributes to DNA repair and genomic stability. Researchers use SUN1 antibody to study nuclear organization, mechanobiology, and chromosome dynamics.
Clinically, SUN1 mutations and dysregulation are associated with laminopathies, muscular dystrophies, and neurodevelopmental disorders. Disruption of the LINC complex impairs nuclear positioning and mechanosignaling, leading to disease. SUN1 also contributes to cancer progression by altering nuclear morphology and chromatin organization. NSJ Bioreagents provides SUN1 antibody for research in nuclear architecture, mechanobiology, and disease mechanisms.
Experimentally, SUN1 antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to visualize nuclear envelope localization, and in immunohistochemistry to study tissue-specific expression. Co-immunoprecipitation with SUN1 antibody identifies binding partners within the LINC complex. -
UniProt
- O94901
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途径
- Maintenance of Protein Location
抗原
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