HIP1R 抗体 (AA 316-734)
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北京 101111
Quick Overview for HIP1R 抗体 (AA 316-734) (ABIN7873892)
抗原
See all HIP1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 316-734
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原理
- HIP1R Antibody / Huntingtin-interacting protein 1-related protein
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids E316-E734) was used as the immunogen for the HIP1R antibody.
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亚型
- IgG
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anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 1-1068) antibody
HIP1R 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 969-1066) antibodyHIP1R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 1-1068) antibodyHIP1R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 304-487) antibodyHIP1R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (N-Term) antibodyHIP1R 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 98-126), (N-Term) antibodyHIP1R 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18066 unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 771-1012) antibodyHIP1R 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 300-600) antibodyHIP1R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 300-350) antibodyHIP1R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 1-50) antibodyHIP1R 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HIP1R antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HIP1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))
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别名
- HIP1R
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背景
- Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. Huntingtin-interacting protein 1-related protein, or HIP1R, was identified on the basis of its structural homology with Huntingtin-interacting protein 1, or HIP1. Based on its domain structure, HIP1R is a putative endocytosis-related protein. Knockdown of HIP1R impairs the endocytosis of activated epidermal growth factor receptor (EGFR) and the consequent activation of the downstream ERK and Akt proteins. Additionally, HIP1R is a component of the clathrin-coated pits and vesicles, which in part links the endocytic machinery to the actin cytoskeleton. It binds to 3-phosphoinositides via ENTH domains to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1R deficiency significantly reduces the expression of the ionotropic glutamate receptor GluA1, GluN2A, and GluN2B subunits, but not the GABAA receptor ?1 subunit. Knockdown of HIP1R reduces the amplitude and frequency of the miniature excitatory postsynaptic current, but not of the miniature inhibitory postsynaptic curren. HIP1R has been identified as a protein that can target histone deacetylase-3-mediated neurodegeneration, along with other proteins like NPTX1, NFL, TEX10, and TGFFG.
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UniProt
- O75146
抗原
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