PYGL 抗体 (AA 313-804)
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Quick Overview for PYGL 抗体 (AA 313-804) (ABIN7873854)
抗原
See all PYGL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 313-804
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原理
- PYGL Antibody / Glycogen phosphorylase, Liver
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids K313-K804) was used as the immunogen for the PYGL antibody.
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亚型
- IgG
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anti-phosphorylase, Glycogen, Liver (PYGL) (AA 370-538) antibody
PYGL 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 1-280) antibodyPYGL 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 2-846) antibodyPYGL 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) antibodyPYGL 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 1-847) antibodyPYGL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 341-509) antibodyPYGL 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 809-843) antibodyPYGL 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB53470 unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (Internal Region) antibodyPYGL 适用: 人, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (C-Term) antibodyPYGL 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphorylase, Glycogen, Liver (PYGL) (AA 603-750) antibodyPYGL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PYGL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PYGL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PYGL (phosphorylase, Glycogen, Liver (PYGL))
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别名
- PYGL
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背景
- Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL gene on chromosome 14. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
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UniProt
- P06737
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途径
- Carbohydrate Homeostasis, Cellular Glucan Metabolic Process
抗原
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