SCARA5 抗体 (AA 31-288)
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北京 101111
Quick Overview for SCARA5 抗体 (AA 31-288) (ABIN7873777)
抗原
See all SCARA5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-288
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原理
- SCARA5 Antibody / Scavenger receptor class A member 5
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SCARA5 recombinant protein (Position: K31-R288) was used as the immunogen for the SCARA5 antibody.
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亚型
- IgG
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anti-Scavenger Receptor Class A, Member 5 (SCARA5) (AA 118-495) antibody
SCARA5 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class A, Member 5 (SCARA5) (C-Term) antibodySCARA5 适用: 人, 小鼠 ELISA, WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class A, Member 5 (SCARA5) (AA 303-428) antibodySCARA5 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class A, Member 5 (SCARA5) (AA 392-421), (C-Term) antibodySCARA5 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class A, Member 5 (SCARA5) (C-Term) antibodySCARA5 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class A, Member 5 (SCARA5) (C-Term) antibodySCARA5 适用: 人, 小鼠 ELISA, WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SCARA5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SCARA5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SCARA5 (Scavenger Receptor Class A, Member 5 (SCARA5))
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别名
- SCARA5
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背景
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SCARA5 antibody detects Scavenger receptor class A member 5, a pattern recognition receptor that mediates endocytosis of modified lipoproteins and iron-bound ligands. The UniProt recommended name is Scavenger receptor class A member 5 (SCARA5). This type II transmembrane protein participates in host defense, cellular adhesion, and iron metabolism.
Functionally, SCARA5 antibody identifies a 495-amino-acid receptor consisting of a collagen-like domain, a coiled-coil stalk, and a C-terminal scavenger receptor cysteine-rich domain that binds various ligands. SCARA5 acts as a ferritin receptor, mediating non-transferrin-dependent iron uptake. It also recognizes bacterial components and oxidized lipoproteins, linking innate immune recognition with metabolic regulation.
The SCARA5 gene is located on chromosome 8p21.1 and is highly expressed in kidney, lung, and heart. SCARA5 localizes to the plasma membrane and endocytic vesicles, facilitating internalization of ferritin and other ligands. It contributes to maintaining iron homeostasis and protecting tissues from oxidative stress caused by excess free iron.
Pathologically, downregulation of SCARA5 expression has been reported in several cancers, including hepatocellular and renal carcinoma, suggesting a tumor suppressive role. By controlling iron uptake and reactive oxygen species balance, SCARA5 helps limit oxidative damage and cell proliferation. Research using SCARA5 antibody aids in studying iron metabolism, scavenger receptor function, and innate immunity.
SCARA5 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect receptor expression in tissues and cells. NSJ Bioreagents provides SCARA5 antibody reagents optimized for studies of receptor-mediated endocytosis, iron homeostasis, and tumor biology.
Structurally, Scavenger receptor class A member 5 features a collagenous triple-helical domain that promotes trimerization and ligand binding, resembling other scavenger receptor family members. This antibody enables analysis of SCARA5i 1/2s contribution to innate immunity, oxidative stress defense, and cancer suppression. -
UniProt
- Q6ZMJ2
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途径
- Transition Metal Ion Homeostasis
抗原
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