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Claudin 18 抗体 (AA 31-261)

The 兔 多克隆 anti-Claudin 18 antibody is suitable to detect Claudin 18 in samples from 人 和 大鼠. It has been validated for WB, ELISA, FACS, IF 和 IHC (p).
产品编号 ABIN7873758
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Claudin 18 抗体 (AA 31-261) (ABIN7873758)

抗原

See all Claudin 18 (CLDN18) 抗体
Claudin 18 (CLDN18)

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Claudin 18 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 31-261

    原理

    Claudin 18 Antibody / CLDN18

    纯化方法

    Antigen affinity purified

    免疫原

    Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the Claudin 18 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    Claudin 18 (CLDN18)

    别名

    Claudin 18

    背景

    Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

    UniProt

    P56856

    途径

    Cell-Cell Junction Organization, Hepatitis C
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