Claudin 18 抗体 (AA 31-261)
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Quick Overview for Claudin 18 抗体 (AA 31-261) (ABIN7873758)
抗原
See all Claudin 18 (CLDN18) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-261
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原理
- Claudin 18 Antibody / CLDN18
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Claudin 18 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Claudin 18 (CLDN18)
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别名
- Claudin 18
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背景
- Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
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UniProt
- P56856
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途径
- Cell-Cell Junction Organization, Hepatitis C
抗原
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