IVNS1ABP 抗体 (AA 30-580)
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Quick Overview for IVNS1ABP 抗体 (AA 30-580) (ABIN7873592)
抗原
See all IVNS1ABP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-580
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原理
- IVNS1ABP Antibody / Influenza virus NS1A-binding protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human IVNS1ABP recombinant protein (Position: Q30-D580) was used as the immunogen for the IVNS1ABP antibody.
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亚型
- IgG
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anti-Influenza Virus NS1A Binding Protein (IVNS1ABP) (AA 1-100) antibody
IVNS1ABP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B1 unconjugated
anti-Influenza Virus NS1A Binding Protein (IVNS1ABP) (N-Term) antibodyIVNS1ABP 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 豚鼠, Pig, 马, 兔, 猴, 非洲爪蟾, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Influenza Virus NS1A Binding Protein (IVNS1ABP) (AA 401-642) antibodyIVNS1ABP 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Influenza Virus NS1A Binding Protein (IVNS1ABP) (AA 47-96) antibodyIVNS1ABP 适用: 人, 犬, Cow, 豚鼠, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Influenza Virus NS1A Binding Protein (IVNS1ABP) (N-Term) antibodyIVNS1ABP 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 豚鼠, Pig, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the IVNS1ABP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the IVNS1ABP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IVNS1ABP (Influenza Virus NS1A Binding Protein (IVNS1ABP))
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别名
- IVNS1ABP
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物质类
- Influenza Protein
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背景
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IVNS1ABP antibody detects Influenza virus NS1A-binding protein, a multifunctional nuclear protein involved in RNA processing, chromatin remodeling, and stress responses. IVNS1ABP interacts with the influenza virus NS1A protein, modulating viral replication, but also has critical host cellular functions in normal physiology. It associates with transcriptional and splicing machinery, influences ribonucleoprotein complex assembly, and regulates cell growth and differentiation. The IVNS1ABP antibody is widely employed in studies of host-virus interactions, RNA metabolism, and nuclear architecture.
IVNS1ABP is encoded by the IVNS1ABP gene on human chromosome 1p13.3 and produces a protein of approximately 72 kDa. The protein contains multiple WD40 repeats that mediate protein-protein interactions and a nuclear localization signal that directs it to nucleoplasmic and speckle regions. IVNS1ABP interacts with heterogeneous nuclear ribonucleoproteins (hnRNPs), transcriptional regulators, and chromatin remodelers such as BRG1. Its diverse set of interactions positions it as a hub protein coordinating mRNA maturation and transport.
Research using the IVNS1ABP antibody shows that it contributes to the regulation of pre-mRNA splicing, ribosome biogenesis, and stress granule dynamics. Upon viral infection, IVNS1ABP binds to influenza NS1A protein, enhancing viral mRNA processing and nuclear export. However, under normal conditions, it supports cell survival and proliferation through stabilization of specific RNA-protein complexes. Western blot analysis typically identifies a band near 90 kDa, while immunofluorescence reveals nuclear and nucleolar staining. Loss of IVNS1ABP disrupts splicing patterns and increases sensitivity to stress-induced apoptosis.
Beyond viral interactions, IVNS1ABP is linked to cell differentiation and cytoskeletal organization. It modulates actin dynamics by interacting with profilin and other actin-binding proteins, connecting nuclear signaling with cytoplasmic architecture. Dysregulation of IVNS1ABP has been implicated in developmental disorders and certain cancers. NSJ Bioreagents provides a validated IVNS1ABP antibody optimized for western blot, immunofluorescence, and co-immunoprecipitation applications. This reagent enables researchers to explore RNA processing, host-pathogen interactions, and transcriptional control mediated by this multifunctional nuclear protein. -
UniProt
- Q9Y6Y0
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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