PBX4 抗体 (AA 3-355)
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北京 101111
Quick Overview for PBX4 抗体 (AA 3-355) (ABIN7873538)
抗原
See all PBX4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-355
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原理
- PBX4 Antibody / Pre-B-cell leukemia transcription factor 4
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PBX4 recombinant protein (Position: A3-Q355) was used as the immunogen for the PBX4 antibody.
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亚型
- IgG
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anti-Pre-B-Cell Leukemia Homeobox 4 (PBX4) (AA 319-374) antibody
PBX4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Pre-B-Cell Leukemia Homeobox 4 (PBX4) (AA 319-374) antibodyPBX4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Pre-B-Cell Leukemia Homeobox 4 (PBX4) (Internal Region) antibodyPBX4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PBX4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PBX4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PBX4 (Pre-B-Cell Leukemia Homeobox 4 (PBX4))
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别名
- PBX4
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背景
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The PBX4 antibody targets Pre-B-cell leukemia transcription factor 4, a nuclear homeobox protein encoded by the PBX4 gene. PBX4 is a member of the TALE (three amino acid loop extension) class of homeodomain transcription factors that regulate gene expression during development, differentiation, and organogenesis. By forming heterodimeric or trimeric complexes with HOX and MEIS family proteins, Pre-B-cell leukemia transcription factor 4 modulates the transcription of genes involved in skeletal formation, hematopoiesis, and reproductive system development. The PBX4 antibody provides a powerful reagent for exploring transcriptional control mechanisms mediated by this developmental regulator.
Pre-B-cell leukemia transcription factor 4 contains a conserved homeodomain that binds DNA at specific sequence motifs and an N-terminal domain that mediates protein-protein interactions. It functions both as a transcriptional activator and repressor depending on its cofactors and target promoters. The PBX4 antibody enables visualization of nuclear expression and quantification of PBX4 across tissue types, supporting studies into gene regulatory networks controlling pattern formation and organ differentiation.
PBX family proteins act as cofactors for HOX transcription factors, enhancing DNA-binding specificity and transcriptional activation of developmental genes. PBX4 is expressed in gonadal, skeletal, and neural tissues, where it helps coordinate morphogenesis and cell lineage specification. The PBX4 antibody supports detailed characterization of these expression domains in embryonic and adult tissues. Functional studies suggest PBX4 may also influence germ cell maturation and fertility by regulating genes involved in testis differentiation.
In cancer biology, aberrant PBX expression contributes to oncogenesis by altering transcriptional programs that control proliferation and differentiation. Elevated PBX4 levels have been linked to tumor growth, epithelial-mesenchymal transition, and metastasis in several cancers. The PBX4 antibody enables detection of these expression changes and supports functional studies investigating its role in oncogenic transcriptional regulation. Western blotting and immunohistochemical analysis using this antibody reveal nuclear localization typical of transcription factors.
The PBX4 antibody performs effectively in immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation, providing versatility across molecular and developmental biology applications. NSJ Bioreagents offers this reagent with validated specificity for reproducible detection of Pre-B-cell leukemia transcription factor 4. By supporting investigations into gene regulation, development, and disease, the PBX4 antibody contributes to ongoing research that clarifies how TALE homeodomain proteins orchestrate transcriptional control during differentiation and pathogenesis. -
UniProt
- Q9BYU1
抗原
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