RILPL1 抗体 (AA 3-324)
Our Local Distributor
北京 101111
Quick Overview for RILPL1 抗体 (AA 3-324) (ABIN7873534)
抗原
See all RILPL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 3-324
-
原理
- RILPL1 Antibody / Rab interacting lysosomal protein like 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human RILPL1 recombinant protein (Position: E3-K324) was used as the immunogen for the RILPL1 antibody.
-
亚型
- IgG
-
-
anti-Rab Interacting Lysosomal Protein-Like 1 (RILPL1) (AA 1-362) antibody
RILPL1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Rab Interacting Lysosomal Protein-Like 1 (RILPL1) (N-Term) antibodyRILPL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Rab Interacting Lysosomal Protein-Like 1 (RILPL1) (AA 344-374), (C-Term) antibodyRILPL1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Rab Interacting Lysosomal Protein-Like 1 (RILPL1) (N-Term) antibodyRILPL1 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Rab Interacting Lysosomal Protein-Like 1 (RILPL1) (AA 337-366), (C-Term) antibodyRILPL1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB27803 unconjugated
-
-
应用备注
- Optimal dilution of the RILPL1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the RILPL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- RILPL1 (Rab Interacting Lysosomal Protein-Like 1 (RILPL1))
-
别名
- RILPL1
-
背景
-
RILPL1 antibody detects Rab interacting lysosomal protein like 1, encoded by the RILPL1 gene. Rab interacting lysosomal protein like 1 is a cytoplasmic protein associated with endosomal and lysosomal trafficking pathways and contributes to cellular transport processes. RILPL1 antibody provides researchers with a specific reagent for studying vesicle transport, Rab protein signaling, and lysosomal dynamics.
Rab interacting lysosomal protein like 1 belongs to a small family of proteins that interact with Rab GTPases. Research using RILPL1 antibody has shown that it participates in Rab8 and Rab10 mediated trafficking, regulating transport between recycling endosomes and lysosomes. This activity ensures accurate sorting of proteins and maintenance of membrane compartments. By stabilizing Rab interactions, RILPL1 promotes directional transport required for cell polarity and homeostasis.
Studies with RILPL1 antibody have demonstrated roles in neuronal cells. Rab interacting lysosomal protein like 1 regulates ciliogenesis and dendritic transport, contributing to neuronal morphology and signaling. Defects in RILPL1 expression have been associated with impaired ciliogenesis, which is linked to developmental disorders and neurodegeneration. These findings highlight its importance in specialized trafficking pathways of neurons.
In disease contexts, RILPL1 has been implicated in Parkinson disease. Research using RILPL1 antibody has shown that it interacts with LRRK2, a kinase mutated in familial Parkinson disease. Phosphorylation of Rab proteins by LRRK2 alters RILPL1 mediated trafficking, leading to lysosomal stress and defective autophagy. This suggests that RILPL1 is an important mediator of neurodegenerative pathology through its interaction with disease-associated signaling pathways.
RILPL1 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies protein levels and detects post-translational changes, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates subcellular localization to vesicular compartments. These methods make RILPL1 antibody valuable in cell biology and neuroscience research.
By providing validated RILPL1 antibody reagents, NSJ Bioreagents supports studies into Rab signaling, vesicle trafficking, and neurodegeneration. Detection of Rab interacting lysosomal protein like 1 provides researchers with insights into how vesicular transport pathways influence development and disease. -
UniProt
- Q5EBL4
抗原
-
