SRR 抗体 (AA 3-283)
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北京 101111
Quick Overview for SRR 抗体 (AA 3-283) (ABIN7873531)
抗原
See all SRR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-283
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原理
- Serine racemase Antibody / SRR
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Serine racemase/SRR recombinant protein (Position: A3-E283) was used as the immunogen for the Serine racemase antibody.
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亚型
- IgG
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anti-Serine Racemase (SRR) antibody
KD Validated SRR 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2345 unconjugated Recombinant Antibody
anti-Serine Racemase (SRR) (AA 1-100) antibodySRR 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (AA 1-340) antibodySRR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (AA 1-340) antibodySRR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (C-Term) antibodySRR 适用: 人, 大鼠, 小鼠, Cow, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Serine racemase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Serine racemase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SRR (Serine Racemase (SRR))
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别名
- Serine racemase
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背景
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Serine racemase antibody detects Serine racemase, encoded by the SRR gene on chromosome 17p13.3. Serine racemase antibody is widely used in research on amino acid metabolism, neurotransmission, and neurodegeneration. Serine racemase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of L-serine to D-serine, a co-agonist of NMDA receptors. This enzyme plays a central role in modulating glutamatergic neurotransmission and synaptic plasticity in the brain.
Structurally, Serine racemase is a ~37 kDa cytosolic protein containing a PLP-binding site and catalytic lysine essential for racemization activity. It forms homodimers, which stabilize enzymatic activity. In addition to racemization, Serine racemase can catalyze beta-elimination of water from serine to generate pyruvate, linking it to energy metabolism. Isoforms generated by alternative splicing display altered enzymatic properties.
Functionally, Serine racemase regulates D-serine availability, which acts at NMDA receptor glycine-binding sites to facilitate excitatory neurotransmission. This regulation influences synaptic plasticity, learning, and memory. Knockout studies demonstrate that loss of Serine racemase reduces D-serine levels, impairing NMDA receptor function. Researchers use Serine racemase antibody to study glutamatergic signaling, synaptic physiology, and neuropsychiatric disease.
Clinically, Serine racemase is implicated in schizophrenia, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and other neurological disorders. Reduced D-serine levels contribute to NMDA receptor hypofunction in schizophrenia, while elevated levels may cause excitotoxicity in ALS. Pharmacological modulation of Serine racemase activity is under investigation for treating these conditions. NSJ Bioreagents provides Serine racemase antibody for research in neurobiology, neurotransmission, and neurodegeneration.
Experimentally, Serine racemase antibody is used in western blotting to detect the ~37 kDa protein, in immunofluorescence microscopy to examine neuronal localization, and in immunohistochemistry to study brain distribution. Co-immunoprecipitation with Serine racemase antibody identifies interacting proteins such as GRIP and Golga3. -
UniProt
- Q9GZT4
抗原
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