BCR 抗体 (AA 3-264)
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Quick Overview for BCR 抗体 (AA 3-264) (ABIN7873528)
抗原
See all BCR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-264
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原理
- Breakpoint cluster region protein Antibody / BCR
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids D3-N264) was used as the immunogen for the Breakpoint cluster region protein antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Breakpoint cluster region protein antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Breakpoint cluster region protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- BCR (Breakpoint Cluster Region (BCR))
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别名
- Breakpoint cluster region protein
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背景
- The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
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UniProt
- P11274
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途径
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
抗原
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