ITPKC 抗体 (AA 292-607)
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Quick Overview for ITPKC 抗体 (AA 292-607) (ABIN7873450)
抗原
See all ITPKC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 292-607
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原理
- ITPKC Antibody / Inositol-trisphosphate 3-kinase C
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ITPKC recombinant protein (Position: D292-E607) was used as the immunogen for the ITPKC antibody.
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亚型
- IgG
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anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (AA 89-117), (N-Term) antibody
ITPKC 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23817 unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (N-Term) antibodyITPKC 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) antibodyITPKC 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (AA 96-125), (N-Term) antibodyITPKC 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) antibodyITPKC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (AA 63-161) antibodyITPKC 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (Internal Region) antibodyVerified ITPKC 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (AA 1-683) antibodyITPKC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ITPKC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ITPKC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ITPKC (Inositol-Trisphosphate 3-Kinase C (ITPKC))
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别名
- ITPKC
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背景
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ITPKC antibody detects Inositol-trisphosphate 3-kinase C, a signaling enzyme that phosphorylates inositol 1,4,5-trisphosphate (IP3) to generate inositol 1,3,4,5-tetrakisphosphate (IP4). ITPKC serves as a critical regulator of intracellular calcium signaling, immune activation, and vascular inflammation. The ITPKC antibody is widely used in immunology, signal transduction, and cardiovascular research to study calcium homeostasis and immune cell regulation.
ITPKC is encoded by the ITPKC gene located on human chromosome 19q13.2. The protein is approximately 461 amino acids long and localizes to the cytoplasm, where it modulates calcium flux by regulating IP3 metabolism. Through phosphorylation of IP3, ITPKC reduces calcium release from the endoplasmic reticulum, thereby attenuating NFAT activation and T-cell proliferation.
The ITPKC antibody detects a 52 kilodalton band by western blot and exhibits diffuse cytoplasmic staining under fluorescence microscopy. ITPKC plays a pivotal role in immune regulation, particularly in T-cell receptor signaling. Genetic variants of ITPKC are associated with Kawasaki disease, an inflammatory vascular disorder, due to dysregulated calcium-dependent immune activation.
Beyond immunity, ITPKC influences endothelial barrier function and smooth muscle contraction, linking it to cardiovascular homeostasis. It also interacts with other kinases and phosphatases in the phosphoinositide signaling pathway, integrating metabolic and signaling cues. In cancer cells, ITPKC expression affects proliferation and angiogenesis by controlling intracellular calcium oscillations.
Because of its dual role in immune and vascular signaling, ITPKC is a key enzyme at the crossroads of inflammation and calcium dynamics. NSJ Bioreagents provides a validated ITPKC antibody optimized for its applications, supporting research into immune regulation, vascular biology, and phosphoinositide metabolism. -
UniProt
- Q96DU7
抗原
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