RFXANK 抗体 (AA 29-260)
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Quick Overview for RFXANK 抗体 (AA 29-260) (ABIN7873407)
抗原
See all RFXANK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 29-260
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原理
- RFXANK Antibody / Regulatory factor X-associated ankyrin-containing protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RFXANK recombinant protein (Position: E29-E260) was used as the immunogen for the RFXANK antibody.
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亚型
- IgG
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anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) antibody
RFXANK 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) (AA 1-90) antibodyRFXANK 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G10 unconjugated
anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) (AA 3-84) antibodyRFXANK 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) antibodyRFXANK 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) (AA 1-237) antibodyRFXANK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) (AA 1-237) antibodyRFXANK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RFXANK antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RFXANK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))
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别名
- RFXANK
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背景
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RFXANK antibody detects Regulatory factor X-associated ankyrin-containing protein, a transcriptional regulator essential for major histocompatibility complex (MHC) class II gene expression. The UniProt recommended name is Regulatory factor X-associated ankyrin-containing protein (RFXANK). This nuclear protein forms part of the RFX complex with RFX5 and RFXAP, which binds to X-box promoter elements and activates MHC class II transcription.
Functionally, RFXANK antibody identifies a 260-amino-acid nuclear protein containing multiple ankyrin repeats that mediate protein-protein interactions within the RFX complex. RFXANK acts as a scaffold for assembling the class II transactivator (CIITA) and other coactivators at MHC class II promoters, enabling antigen-presenting cells to express HLA-D gene products critical for immune recognition.
The RFXANK gene is located on chromosome 19p12 and is highly expressed in antigen-presenting cells such as B lymphocytes, macrophages, and dendritic cells. Its function is indispensable for adaptive immune activation and T-cell mediated responses.
Pathologically, mutations in RFXANK cause bare lymphocyte syndrome type II (BLS II), a severe immunodeficiency characterized by loss of MHC class II expression and defective antigen presentation. Research using RFXANK antibody supports studies in transcriptional regulation, immunodeficiency, and antigen presentation biology.
RFXANK antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcriptional regulators involved in immune gene activation. NSJ Bioreagents provides RFXANK antibody reagents optimized for immunology, transcription, and genetic disease research.
Structurally, Regulatory factor X-associated ankyrin-containing protein contains tandem ankyrin repeats and a nuclear localization signal that mediate its assembly into DNA-binding complexes. This antibody enables investigation of RFXANK's role in immune gene transcription and MHC regulation. -
UniProt
- O14593
抗原
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