GRB7 抗体 (AA 29-256)
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Quick Overview for GRB7 抗体 (AA 29-256) (ABIN7873405)
抗原
See all GRB7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 29-256
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原理
- GRB7 Antibody / Growth factor receptor-bound protein 7
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids R29-S256) was used as the immunogen for the GRB7 antibody.
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 298-489) antibody
GRB7 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 66-327) antibodyGRB7 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 37-136) antibodyGRB7 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) antibodyKD Validated GRB7 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB6000 unconjugated Recombinant Antibody
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 233-532) antibodyGRB7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) antibodyGRB7 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 124-141), (Middle Region) antibodyGRB7 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (N-Term) antibodyVerified GRB7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GRB7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GRB7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
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别名
- GRB7
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背景
- GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase(FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2(alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified(present in excess copies) in breast cancers. GRB7 though to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
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UniProt
- Q14451
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途径
- EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
抗原
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