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RBP4 抗体 (AA 29-148)

The 小鼠 单克隆 anti-RBP4 antibody is suitable to detect RBP4 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7873350
发货至: 中国
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Quick Overview for RBP4 抗体 (AA 29-148) (ABIN7873350)

抗原

See all RBP4 抗体
RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

适用

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宿主

  • 145
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小鼠

克隆类型

  • 137
  • 113
单克隆

标记

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This RBP4 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

RBP4-4047
  • 抗原表位

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    AA 29-148

    原理

    RBP4 Antibody / Retinol Binding Protein 4 (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    A portion of amino acids 29-148 from the human protein was used as the immunogen for the RBP4 antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the RBP4 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the RBP4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

    别名

    RBP4

    背景

    Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

    UniProt

    P02753

    途径

    Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response
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