Recombinant Ki-67 抗体 (AA 2860-3256)
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北京 101111
Quick Overview for Recombinant Ki-67 抗体 (AA 2860-3256) (ABIN7873322)
抗原
See all Ki-67 (MKI67) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2860-3256
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原理
- Ki-67 Antibody / MKI67
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纯化方法
- Affinity chromatography
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免疫原
- Recombinant protein with human Ki67 (Position: K2860-I3256) was used as the immunogen for the Ki-67 antibody.
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亚型
- IgG
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anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1201-1300) antibody
MKI67 适用: 人, 小鼠, 大鼠, 兔, 山羊 ELISA, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1160-1493) antibodyMKI67 适用: 人 IHC, WB, IHC (p) 宿主: 大鼠 Monoclonal 9C3 unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 2293-2478) antibodyMKI67 适用: 人 IHC, WB, FACS, IF 宿主: 小鼠 Monoclonal MKI67-2461 unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 2293-2478) antibodyMKI67 适用: 人 IHC, WB, FACS, IF 宿主: 小鼠 Monoclonal MKI67-2462 unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 2815-2928) antibodyMKI67 适用: 人 IHC, WB, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1200-1250) antibodyMKI67 适用: 人 IHC, FACS, ICC, IF/ICC, IF (p), mIF 宿主: 兔 Monoclonal BLR021E unconjugated Recombinant Antibody
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1200-1250) antibodyMKI67 适用: 人 IHC, FACS, ICC, IF/ICC, IF (p), mIF 宿主: 兔 Monoclonal BLR021E unconjugated Recombinant Antibody
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1160-1493) antibodyMKI67 适用: 人 IHC, WB, FACS, ELISA 宿主: 小鼠 Monoclonal 7B12B1 unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 2924-3256) antibodyMKI67 适用: 人 IHC, IHC (p) 宿主: 小鼠 Monoclonal 8H5 unconjugated
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) (AA 1160-1493) antibodyMKI67 适用: 人 IHC, IHC (p) 宿主: 大鼠 Monoclonal 5B10 unconjugated
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应用备注
- Optimal dilution of the Ki-67 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Ki-67 antibody at -20oC.
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- Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
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别名
- Ki-67
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背景
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Ki-67 antibody detects the protein Ki-67, encoded by the MKI67 gene. Ki-67 is a nuclear protein expressed in proliferating cells and is one of the most widely used markers for cellular proliferation in research and clinical diagnostics. This protein is absent in resting cells (G0) but present during all active phases of the cell cycle, including G1, S, G2, and mitosis. Ki-67 antibody provides researchers with an essential tool to measure cell proliferation rates, assess tumor aggressiveness, and evaluate treatment responses in cancer studies. Its widespread use in histopathology reflects its reliability as a biomarker for growth activity.
Ki-67 is involved in ribosomal RNA transcription and organization of the nucleolus during interphase. During mitosis, it localizes to the perichromosomal layer, forming a structural scaffold that helps protect chromosomes and maintain proper segregation. Studies using Ki-67 antibody have revealed that depletion of this protein disrupts chromosomal condensation and segregation, underscoring its functional roles beyond serving as a proliferation marker. These insights have expanded its importance from being a passive marker of division to an active participant in cell cycle regulation.
In cancer biology, Ki-67 is one of the most important clinical biomarkers. Tumor samples are routinely stained with Ki-67 antibody to determine the proliferation index, which correlates with tumor grade, aggressiveness, and prognosis. High Ki-67 labeling indices are observed in fast-growing tumors such as breast, prostate, and brain cancers, and are associated with poor outcomes. Conversely, lower Ki-67 indices are linked to slower-growing neoplasms and better survival rates. Pathologists use Ki-67 antibody immunohistochemistry to quantify nuclear staining percentages in tumor biopsies, providing valuable prognostic information.
Beyond oncology, Ki-67 antibody is applied in regenerative biology and developmental studies. Since this protein marks actively dividing cells, it is used to track stem cell proliferation, tissue regeneration, and embryonic development. Immunofluorescence assays with Ki-67 antibody help identify proliferative niches in tissues such as bone marrow, gut, and brain. Flow cytometry can also measure Ki-67 expression at the single-cell level, making it useful in studies of immune activation, hematopoietic stem cell dynamics, and vaccine responses.
By supplying validated Ki-67 antibody reagents, NSJ Bioreagents enables researchers to study both the biological roles of this protein and its diagnostic utility. The ability to detect proliferating cells across experimental systems makes Ki-67 antibody indispensable in cancer research, clinical pathology, and developmental biology. -
UniProt
- P46013
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途径
- Glycosaminoglycan Metabolic Process
抗原
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