PDZD8 抗体 (AA 28-1146)
The 兔 多克隆 anti-PDZD8 antibody (ABIN7873225) specifically detects PDZD8 in WB, ELISA, FACS, IF 和 IHC.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7873225
发货至:
中国
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Contact Info
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中国
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Quick Overview for PDZD8 抗体 (AA 28-1146) (ABIN7873225)
抗原
See all PDZD8 抗体
PDZD8
(PDZ Domain Containing 8 (PDZD8))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This PDZD8 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
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抗原表位
- AA 28-1146
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原理
- PDZD8 Antibody / PDZ domain-containing protein 8
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PDZD8 recombinant protein (Position: R28-D1146) was used as the immunogen for the PDZD8 antibody.
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亚型
- IgG
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anti-PDZ Domain Containing 8 (PDZD8) (AA 949-1058) antibody
PDZD8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E3 unconjugated
anti-PDZ Domain Containing 8 (PDZD8) (AA 949-1058) antibodyPDZD8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PDZD8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PDZD8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PDZD8 (PDZ Domain Containing 8 (PDZD8))
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别名
- PDZD8
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背景
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PDZD8 antibody targets PDZ domain-containing protein 8, a membrane-associated scaffolding protein involved in organelle tethering, lipid transfer, and calcium signaling. Encoded by the PDZD8 gene, this multidomain protein contains PDZ, C1, and coiled-coil regions that mediate interactions with multiple organelle and cytoskeletal proteins. PDZD8 plays a crucial role in forming membrane contact sites between the endoplasmic reticulum (ER) and mitochondria, facilitating lipid exchange and calcium ion transport essential for energy metabolism and cellular homeostasis.
Recent studies have shown that PDZD8 acts as a functional ortholog of yeast Mmm1-Mdm12 complex components in establishing ER-mitochondrial contacts. By bridging the two organelles, PDZD8 helps coordinate mitochondrial dynamics and calcium uptake during neuronal signaling and metabolic activity. Loss of PDZD8 disrupts mitochondrial morphology, impairs synaptic transmission, and affects neuronal energy balance, highlighting its importance in brain physiology. The protein is also implicated in autophagy regulation, as it contributes to the spatial organization of membrane contact sites during autophagosome formation.
The PDZD8 gene is located on chromosome 10q25.3 and encodes multiple isoforms through alternative splicing. The protein localizes to the ER membrane via its C-terminal transmembrane domain and interacts with small GTPases and lipid transport proteins. Dysregulation of PDZD8 has been associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease, where altered organelle tethering and calcium imbalance contribute to pathogenesis.
Immunohistochemical staining using PDZD8 antibody reveals perinuclear and cytoplasmic localization in neurons, hepatocytes, and fibroblasts. The antibody is valuable for investigating ER-mitochondrial contact formation, calcium signaling, and membrane lipid metabolism. PDZD8 antibody from NSJ Bioreagents supports research into cellular organelle communication, neurodegenerative mechanisms, and intracellular trafficking. -
UniProt
- Q8NEN9
抗原
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