FTO 抗体 (AA 279-505)
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Quick Overview for FTO 抗体 (AA 279-505) (ABIN7873222)
抗原
See all FTO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 279-505
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原理
- FTO Antibody / Fat mass and obesity associated
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids D279-P505) was used as the immunogen for the FTO antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the FTO antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FTO antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FTO (Fat Mass and Obesity-Associated (FTO))
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别名
- FTO
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背景
- Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
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UniProt
- Q9C0B1
抗原
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