FAM59A 抗体 (AA 277-753)
The 兔 多克隆 anti-FAM59A antibody (ABIN7873213) specifically detects FAM59A in ELISA, WB, IHC 和 FACS.
The antibody is reactive with 人 samples.
产品编号 ABIN7873213
发货至:
中国
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Quick Overview for FAM59A 抗体 (AA 277-753) (ABIN7873213)
抗原
See all FAM59A 抗体
FAM59A
(Family with Sequence Similarity 59, Member A (FAM59A))
适用
人
宿主
兔
克隆类型
多克隆
标记
This FAM59A antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
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抗原表位
- AA 277-753
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原理
- GAREM1 Antibody / GRB2-associated and regulator of MAPK protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GAREM1 recombinant protein (Position: Q277-E753) was used as the immunogen for the GAREM1 antibody.
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亚型
- IgG
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anti-Family with Sequence Similarity 59, Member A (FAM59A) (AA 12-320) antibody
FAM59A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 59, Member A (FAM59A) (C-Term) antibodyFAM59A 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GAREM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GAREM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))
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别名
- GAREM1
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背景
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GAREM1 antibody detects GRB2-associated regulator of MAPK1 subtype 1, an adaptor protein involved in growth factor receptor signaling, particularly within the epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) pathways. GAREM1 acts as a downstream effector of receptor tyrosine kinases and plays a role in mitogen-activated protein kinase (MAPK) signaling, cellular proliferation, and differentiation. The GAREM1 antibody is used to investigate mechanisms of growth factor signaling, cell migration, and oncogenic transformation.
GAREM1 is encoded by the GAREM1 gene located on human chromosome 18p11.32. The protein is approximately 95 kilodaltons and contains multiple functional regions, including a pleckstrin homology (PH) domain, proline-rich motifs, and SH3-binding sequences that facilitate interaction with growth factor receptor-bound protein 2 (GRB2). Through these interactions, GAREM1 acts as a scaffolding adaptor that transmits extracellular growth factor signals to downstream MAPK/ERK cascades, modulating transcriptional responses and cytoskeletal reorganization.
The GAREM1 antibody detects a 90-100 kilodalton protein on western blot and reveals cytoplasmic and perinuclear localization by immunofluorescence. Activation of EGFR or FGFR promotes tyrosine phosphorylation of GAREM1, which enhances its association with signaling molecules such as SHP2, ERK1/2, and SOS1. Functionally, GAREM1 contributes to cell cycle progression and survival, and its overexpression has been observed in certain cancers, including hepatocellular carcinoma and glioblastoma. Depletion or inhibition of GAREM1 disrupts ERK activation, leading to reduced cell proliferation and migration.
GAREM1 also influences differentiation processes by regulating cytoskeletal dynamics and cell adhesion. In neurons, GAREM1 modulates neurite outgrowth and receptor clustering, linking receptor tyrosine kinase signaling to actin remodeling. It may further act as a regulatory hub integrating MAPK and PI3K signaling pathways. NSJ Bioreagents provides a validated GAREM1 antibody optimized for western blot, immunohistochemistry, and immunofluorescence, supporting studies of receptor signaling, cancer cell proliferation, and cellular differentiation. -
UniProt
- Q9H706
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途径
- EGFR Signaling Pathway
抗原
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