Calreticulin 抗体 (AA 277-305)
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北京 101111
Quick Overview for Calreticulin 抗体 (AA 277-305) (ABIN7873209)
抗原
See all Calreticulin (CALR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 277-305
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原理
- CALR Antibody / Calreticulin
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 277-305 from the human protein were used as the immunogen for the CALR antibody.
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亚型
- Ig Fraction
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anti-Calreticulin (CALR) (AA 18-193) antibody
CALR 适用: 人 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (AA 196-310) antibodyCALR 适用: 人 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) antibodyCALR 适用: 人, 小鼠 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 1G6A7 unconjugated
anti-Calreticulin (CALR) (AA 18-417) antibodyCALR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7B3D7 unconjugated
anti-Calreticulin (CALR) (AA 277-305) antibodyCALR 适用: 人, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21112 unconjugated
anti-Calreticulin (CALR) (AA 1-417) antibodyCALR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G11-1A9 unconjugated
anti-Calreticulin (CALR) antibodyCALR 适用: 人 WB, IHC, IP, ICC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (N-Term) antibodyCALR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (AA 18-323) antibodyCALR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) antibody (Biotin)CALR 适用: 人 WB, IHC, IP, ICC, FACS, IF 宿主: 兔 Polyclonal Biotin
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应用备注
- The stated application concentrations are suggested starting points. Titration of the CALR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the CALR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Calreticulin (CALR)
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别名
- CALR
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背景
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
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UniProt
- P27797
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途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
抗原
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