IL-11 抗体 (AA 27-61)
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Quick Overview for IL-11 抗体 (AA 27-61) (ABIN7873137)
抗原
See all IL-11 (IL11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 27-61
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原理
- IL-11 Antibody (N-Terminal Region)
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 27-61 from human IL-11 was used as the immunogen for the IL-11 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the IL-11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the IL-11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- IL-11 (IL11) (Interleukin 11 (IL11))
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别名
- IL-11
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背景
- Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:< a href=http://www.uniprot.org/citations/12919066 target=_blank>12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. [UniProt]
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UniProt
- P20809
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途径
- JAK/STAT Signaling, Negative Regulation of Hormone Secretion
抗原
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