PFKFB4 抗体 (AA 266-296)
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Quick Overview for PFKFB4 抗体 (AA 266-296) (ABIN7873049)
抗原
See all PFKFB4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 266-296
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原理
- PFKFB4 Antibody / PFK/FBPase 4
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 266-296 from the human protein was used as the immunogen for the PFKFB4 antibody.
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亚型
- Ig Fraction
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anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-296) antibody
PFKFB4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB04059 unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibodyPFKFB4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 274-303) antibodyPFKFB4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibodyPFKFB4 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-368) antibodyPFKFB4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow, Pig, Bat, Hamster, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-296) antibodyPFKFB4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the PFKFB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot the PFKFB4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))
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别名
- PFKFB4
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背景
- PFKFB4, also called 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, is a key enzyme involved in the regulation of cellular metabolism. It acts as a regulator of the glycolysis process, which is the breakdown of glucose into energy. This enzyme is crucial for maintaining the balance between energy production and storage within the cell. Research has shown that dysregulation of PFKFB4 can have profound effects on cellular metabolism and ultimately, overall health. For example, overexpression of PFKFB4 has been linked to increased glycolysis and cancer cell proliferation, making it a potential target for cancer therapy. On the other hand, decreased levels of PFKFB4 have been associated with metabolic disorders such as diabetes. One particularly intriguing aspect of PFKFB4 is its dual function as both a kinase and a phosphatase. This unique feature allows it to not only stimulate glycolysis but also inhibit the breakdown of fructose-2,6-biphosphate, a key activator of glycolysis. This dual role gives PFKFB4 a central position in the complex regulatory network of cellular metabolism.
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UniProt
- Q16877
抗原
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