TYMS 抗体 (AA 265-294)
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Quick Overview for TYMS 抗体 (AA 265-294) (ABIN7873043)
抗原
See all TYMS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 265-294
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原理
- Thymidylate Synthase Antibody / TYSY
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 265-294 from the human protein was used as the immunogen for the Thymidylate Synthase Antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Thymidylate Synthase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TYMS (Thymidylate Synthetase (TYMS))
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别名
- Thymidylate Synthase
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背景
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
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UniProt
- P04818
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途径
- Mitotic G1-G1/S Phases
抗原
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