SEPN1 抗体 (AA 260-590)
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Quick Overview for SEPN1 抗体 (AA 260-590) (ABIN7873028)
抗原
See all SEPN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 260-590
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原理
- SEPN1 Antibody / Selenoprotein N / SELENON / SELN
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids H260-P590) was used as the immunogen for the SEPN1 antibody.
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亚型
- IgG
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anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibody
SEPN1 适用: 人, Cow, 豚鼠, 马, 大鼠, Pig, 斑马鱼, 猴, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) antibodySEPN1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, 小鼠, Cow, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (AA 417-445), (C-Term) antibodySEPN1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31326 unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, 小鼠, Cow, 豚鼠, 马, 大鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, Cow, 豚鼠, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (AA 416-445), (C-Term) antibodySEPN1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SEPN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SEPN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SEPN1 (Selenoprotein N, 1 (SEPN1))
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别名
- SEPN1
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背景
- This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.
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UniProt
- Q9NZV5
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途径
- Skeletal Muscle Fiber Development
抗原
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