OSBPL5 抗体 (AA 26-879)
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Quick Overview for OSBPL5 抗体 (AA 26-879) (ABIN7873019)
抗原
See all OSBPL5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-879
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原理
- OSBPL5 Antibody / Oxysterol-binding protein-related protein 5
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human OSBPL5 recombinant protein (Position: R26-K879) was used as the immunogen for the OSBPL5 antibody.
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亚型
- IgG
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anti-Oxysterol Binding Protein-Like 5 (OSBPL5) (N-Term) antibody
Verified OSBPL5 适用: 人, 大鼠 WB, ELISA, IF, FACS, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Oxysterol Binding Protein-Like 5 (OSBPL5) (AA 4-99) antibodyOSBPL5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Oxysterol Binding Protein-Like 5 (OSBPL5) (AA 1-879) antibodyOSBPL5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the OSBPL5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the OSBPL5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- OSBPL5 (Oxysterol Binding Protein-Like 5 (OSBPL5))
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别名
- OSBPL5
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背景
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OSBPL5 antibody detects Oxysterol-binding protein-related protein 5, a lipid transfer protein involved in cholesterol and phospholipid exchange between organelles. OSBPL5 belongs to the oxysterol-binding protein (OSBP) family that mediates lipid homeostasis and endoplasmic reticulum-plasma membrane tethering. The OSBPL5 antibody is used in studies of lipid metabolism, organelle communication, and membrane dynamics.
OSBPL5 is encoded by the OSBPL5 gene located on human chromosome 11q13.1. The protein is approximately 100 kilodaltons and contains a pleckstrin homology (PH) domain, a FFAT motif, and a C-terminal OSBP-like sterol-binding domain. OSBPL5 localizes to membrane contact sites between the endoplasmic reticulum and late endosomes or mitochondria, where it regulates non-vesicular lipid transport.
The OSBPL5 antibody detects a 100 kilodalton band on western blot and exhibits punctate cytoplasmic staining. Functional studies show that OSBPL5 participates in cholesterol redistribution and phosphatidylserine transport, thereby influencing membrane composition and signaling. It also regulates autophagy and mitochondrial dynamics by modulating lipid exchange at organelle interfaces.
OSBPL5 plays roles in metabolism, growth regulation, and reproduction, with high expression in liver, testis, and brain. Dysregulation has been linked to metabolic disorders, including insulin resistance and obesity. NSJ Bioreagents provides a validated OSBPL5 antibody, supporting research into lipid trafficking, membrane homeostasis, and organelle interaction. -
UniProt
- Q9H0X9
抗原
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