TGIF1 抗体 (AA 26-401)
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Quick Overview for TGIF1 抗体 (AA 26-401) (ABIN7873001)
抗原
See all TGIF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-401
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原理
- TGIF1 Antibody / 5-TG-3-interacting factor 1 / TGIF
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids D26-A401) was used as the immunogen for the TGIF1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TGIF1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TGIF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))
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别名
- TGIF1
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背景
- Homeobox protein TGIF1 is a protein that in humans is encoded by the TGIF1 gene. The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.
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UniProt
- Q15583
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途径
- Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation
抗原
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