Recombinant BCL6 抗体 (AA 256-389)
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Quick Overview for Recombinant BCL6 抗体 (AA 256-389) (ABIN7872945)
抗原
See all BCL6 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 256-389
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原理
- Recombinant Bcl6 Antibody (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein (amino acids 256-389) was used as the immunogen for this recombinant Bcl6 antibody.
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亚型
- IgG1, kappa
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anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 501-600) antibody
BCL6 适用: 人 WB, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 ELISA 宿主: 小鼠 Monoclonal BCL6-1527 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 147-276) antibodyBCL6 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2G1B6 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 小鼠 WB, IHC (p), IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 375-425) antibodyBCL6 适用: 人 IHC, WB, FACS, IP, ICC 宿主: 兔 Monoclonal BLR143H unconjugated Recombinant Antibody
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 519-547) antibodyBCL6 适用: 人, 小鼠 IHC, WB, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal BCL6-1982 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 WB 宿主: 小鼠 Monoclonal BCL6-1475 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 大鼠 IHC, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the recombinant Bcl6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant Bcl6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
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别名
- Bcl6
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背景
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Bcl6 antibody recognizes B-cell lymphoma 6 protein, a nuclear transcriptional repressor encoded by the human BCL6 gene. Recombinant Bcl6 antibody detects a zinc finger transcription factor that plays a central role in germinal center formation, B-cell differentiation, and regulation of immune responses. Bcl6 is predominantly localized to the nucleus, where it represses transcription of target genes involved in cell cycle control, DNA damage response, and lymphocyte activation.
Recombinant Bcl6 antibody, also referred to as B-cell lymphoma 6 protein antibody and BCL6 transcription repressor antibody in the literature, targets a member of the BTB-POZ domain zinc finger protein family. Bcl6 contains an N-terminal BTB-POZ domain that mediates transcriptional repression through recruitment of corepressor complexes, as well as multiple C-terminal C2H2-type zinc finger motifs responsible for sequence-specific DNA binding. These structural domains enable Bcl6 to regulate gene expression programs critical for germinal center B-cell proliferation and survival.
The BCL6 gene is located on chromosome 3q27 and is frequently involved in chromosomal translocations in diffuse large B-cell lymphoma and other non-Hodgkin lymphomas. Aberrant expression or mutation of Bcl6 disrupts normal germinal center dynamics and contributes to lymphomagenesis by repressing genes such as TP53 and CDKN1A that are involved in apoptosis and cell cycle arrest.
Bcl6 expression is highly enriched in germinal center B cells and certain T follicular helper cells, reflecting its role in adaptive immunity. In addition to immune regulation, Bcl6 has been implicated in inflammatory signaling pathways and may influence macrophage and dendritic cell function through transcriptional repression of pro-inflammatory genes.
Because of its restricted nuclear expression pattern and strong association with germinal center-derived lymphomas, Bcl6 antibody is widely used in research settings to identify germinal center B cells and to characterize B-cell malignancies. Detection of nuclear Bcl6 supports studies of lymphoid differentiation, tumor classification, and transcriptional regulation mechanisms.
Clone rBCL6/1475 is a recombinant monoclonal antibody designed to target Bcl6 protein in research applications. An antibody to Bcl6 is suitable for detecting nuclear Bcl6 expression and for investigating germinal center biology, transcriptional repression, and lymphoma-related signaling pathways. -
UniProt
- P41182
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途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
抗原
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