HMGCS1 抗体 (AA 251-520)
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Quick Overview for HMGCS1 抗体 (AA 251-520) (ABIN7872930)
抗原
See all HMGCS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 251-520
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原理
- HMGCS1 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids K251-H520) was used as the immunogen for the HMGCS1 antibody.
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亚型
- IgG
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anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 1-238) antibody
HMGCS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 293-467) antibodyHMGCS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 241-520) antibodyHMGCS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 290-317) antibodyHMGCS1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20146 unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) antibodyHMGCS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (Internal Region) antibodyHMGCS1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 360-520) antibodyHMGCS1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 442-470), (C-Term) antibodyHMGCS1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20147 unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) (AA 251-520) antibodyHMGCS1 适用: 人 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1) antibodyHMGCS1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HMGCS1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HMGCS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))
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别名
- HMGCS1
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背景
- Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Cytoplasmic 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS1) catalyzes the first committed step of mevalonate pathway essential for cholesterol biosynthesis. HMGCS1 transcription is regulated by sterol levels. Studies showed that miR-223 reduces cholesterol biosynthesis by inhibiting HMGCS1 and methylsterol monooxygenase 1. In addition, activation of the EGFR family member ERBB4 induces the expression of SREBP-regulated genes (including HMGCS1) involved in cholesterol biosynthesis, suggesting a role of this enzyme in the metabolic re-programming in ERBB4-driven cancers.
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UniProt
- Q01581
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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