GPC2 抗体 (AA 25-498)
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Quick Overview for GPC2 抗体 (AA 25-498) (ABIN7872883)
抗原
See all GPC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-498
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原理
- GPC2 Antibody / Glypican 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Glypican 2/GPC2 recombinant protein (Position: E25-D498) was used as the immunogen for the GPC2 antibody.
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亚型
- IgG
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anti-Glypican 2 (GPC2) antibody
GPC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glypican 2 (GPC2) (AA 136-165), (N-Term) antibodyGPC2 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Glypican 2 (GPC2) (AA 137-165), (N-Term) antibodyGPC2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GPC2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GPC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GPC2 (Glypican 2 (GPC2))
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别名
- GPC2
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背景
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The GPC2 antibody targets Glypican-2, a cell surface heparan sulfate proteoglycan encoded by the GPC2 gene. Glypican-2 is a member of the glypican family that anchors to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage. It modulates signaling pathways such as Wnt, Hedgehog, and fibroblast growth factor (FGF), thereby influencing cell proliferation, differentiation, and neural development. The GPC2 antibody provides researchers with a high-specificity reagent to study membrane-associated signaling regulation and neurodevelopmental processes.
Glypican-2 is predominantly expressed in the developing nervous system, where it regulates neurite outgrowth and synaptic organization. By binding heparan sulfate chains to morphogens and growth factors, GPC2 fine-tunes signal transduction gradients essential for brain patterning. The GPC2 antibody supports detection of this proteoglycan in neuronal cultures and brain tissue, allowing exploration of its role in axonal guidance and synaptic plasticity. GPC2 also interacts with cell adhesion molecules to influence neuronal connectivity during development.
Recent research has identified Glypican-2 as a cell surface oncoprotein in pediatric neuroblastoma. Overexpression of GPC2 enhances cell proliferation and tumor growth through sustained activation of oncogenic signaling pathways. The GPC2 antibody supports investigation of this function, enabling measurement of expression levels in tumor samples and evaluation of therapeutic targeting potential. Antibody-drug conjugates and immunotherapies directed against GPC2 are currently under study for selective tumor eradication.
Beyond neuroblastoma, Glypican-2 contributes to neuronal regeneration and neural stem cell regulation. Its heparan sulfate chains bind multiple signaling ligands, positioning GPC2 as a key modulator of microenvironmental signaling. The GPC2 antibody helps map these ligandi 1/2receptor interactions and track expression changes during neuronal differentiation. Reduced expression of GPC2 has been linked to impaired synaptic signaling, suggesting its importance in maintaining neural circuit stability.
The GPC2 antibody is validated for western blotting, flow cytometry, and immunofluorescence, showing clear cell surface localization consistent with GPI-anchored proteins. NSJ Bioreagents provides this antibody as a validated reagent for reproducible detection in developmental, neurological, and oncology research. By supporting detailed study of Glypican-2 structure and function, the GPC2 antibody advances understanding of membrane-bound proteoglycans in cell signaling and neuroblastoma biology. -
UniProt
- Q8N158
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途径
- Glycosaminoglycan Metabolic Process
抗原
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